The prefecture of Larissa with its capital, Larissa, is a part of the region of Thessaly. It is an important trade center and a node for communications and transportation.

The Mountain Olympus, the highest Greek mountain, is located in the north-eastern part of the prefecture, while the Mount Ossa is located in the east, on the coasts of the Aegean Sea. The Pinios river, which flows from Pindos, crosses the famous Tempi valley between the mountains Olympus and Ossa.

Archaeological surveys indicate that the area of Larissa was inhabited during the Paleolithic period. The control of the region was held by the Thessalian Aleuades until the end of the Macedonian sovereignty, while during the Peloponnesian War in 431 BC, they took the side of the Delian alliance and battled at the side of Athenians. Also, in Larissa, lived and died around the age of 90, the father of the modern medicine, Hippocrates, who was buried somewhere between Tirnavos and Larissa.

The traveler can visit the ancient theater of Larissa which dates back to the 3rd century BC, the Hippocrates monument and the Alcazar Park.

In the prefecture of Larissa, cereals, cotton, tobacco, vegetables, wine and the famous tsipouro (grappa) of the Thessaly are produced and cultivated.

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